Research & Studies
Latest scientific research and clinical studies on ketamine therapy
Showing 1–8 of 8 articles
Ketamine vs. ECT for Treatment-Resistant Depression: Inside the ELEKT-D Trial
The NEJM ELEKT-D trial randomized 403 patients to IV ketamine or ECT for treatment-resistant depression. Here is what it found on response rates, memory effects, and six-month relapse — plus the 2024 and 2025 analyses that complicate the headline.
Esketamine Research Update: Monotherapy Approval, ESCAPE-TRD, and Four-Year Data
Three developments reshaped the esketamine evidence base: ESCAPE-TRD against quetiapine, the 2025 monotherapy trial and FDA approval, and nearly four years of SUSTAIN-3 maintenance data. Here is what each study actually showed.
How Fast Does Ketamine Reduce Suicidal Thoughts? What New Meta-Analyses Show
Two large meta-analyses — 26 trials in JAMA Psychiatry and 49 trials covering nearly 4,000 patients — now quantify how quickly and how long ketamine reduces suicidal ideation, and where the evidence still falls short.
Ketamine for PTSD and OCD: What Recent Randomized Trials Actually Show
Randomized trials of ketamine for PTSD and OCD published since 2023 include striking positive results and one large null trial. A balanced review of what the evidence supports, and what it does not.
Where the Evidence Is Weak: Chronic Pain, Oral Ketamine, and the Placebo Problem
A Cochrane review found no clear benefit for chronic pain, an oral ketamine RCT missed its endpoint, and two trials designed to defeat unblinding failed to separate from placebo. What the negative studies tell patients.
Ketamine Safety Research: Bladder Effects, Dependence Risk, and Monitoring Standards
Systematic reviews published in 2025 examined bladder symptoms across 27 studies and dependence risk across 2,174 patients treated with therapeutic ketamine. Here is what they found, plus FDA warnings and current monitoring standards.
The Neuroscience of Ketamine: How It Promotes Brain Plasticity
A deep dive into the neuroscience behind ketamine therapy — how NMDA antagonism triggers a cascade of molecular events that rapidly restore synaptic connections in the brain.
Key Clinical Trials on Ketamine for Mental Health
A review of landmark clinical trials and recent studies that have shaped our understanding of ketamine's role in treating depression, PTSD, and other conditions.