Knowledge Hub
Evidence-based information and guides on ketamine therapy
Showing 1–12 of 19 articles
Is Ketamine Therapy Right for You? Candidacy, Contraindications, and What to Ask
Ketamine therapy is not right for everyone. Learn the medical and psychiatric factors that determine candidacy, the contraindications that rule it out, the medications that can blunt your results, and what a proper screening consultation should cover.
Ketamine vs. ECT for Treatment-Resistant Depression: Inside the ELEKT-D Trial
The NEJM ELEKT-D trial randomized 403 patients to IV ketamine or ECT for treatment-resistant depression. Here is what it found on response rates, memory effects, and six-month relapse — plus the 2024 and 2025 analyses that complicate the headline.
Esketamine Research Update: Monotherapy Approval, ESCAPE-TRD, and Four-Year Data
Three developments reshaped the esketamine evidence base: ESCAPE-TRD against quetiapine, the 2025 monotherapy trial and FDA approval, and nearly four years of SUSTAIN-3 maintenance data. Here is what each study actually showed.
How Fast Does Ketamine Reduce Suicidal Thoughts? What New Meta-Analyses Show
Two large meta-analyses — 26 trials in JAMA Psychiatry and 49 trials covering nearly 4,000 patients — now quantify how quickly and how long ketamine reduces suicidal ideation, and where the evidence still falls short.
Ketamine for PTSD and OCD: What Recent Randomized Trials Actually Show
Randomized trials of ketamine for PTSD and OCD published since 2023 include striking positive results and one large null trial. A balanced review of what the evidence supports, and what it does not.
Where the Evidence Is Weak: Chronic Pain, Oral Ketamine, and the Placebo Problem
A Cochrane review found no clear benefit for chronic pain, an oral ketamine RCT missed its endpoint, and two trials designed to defeat unblinding failed to separate from placebo. What the negative studies tell patients.
Ketamine Safety Research: Bladder Effects, Dependence Risk, and Monitoring Standards
Systematic reviews published in 2025 examined bladder symptoms across 27 studies and dependence risk across 2,174 patients treated with therapeutic ketamine. Here is what they found, plus FDA warnings and current monitoring standards.
Telehealth Ketamine Prescribing: New Regulations and What They Mean
An overview of evolving regulations around telehealth ketamine prescribing — what changed, why regulators are concerned, and what patients and providers need to know.
Ketamine Therapy Costs: Insurance, Pricing, and Financial Options
A practical guide to the costs of ketamine therapy — what IV infusions and Spravato sessions typically cost, what insurance covers, and financial assistance options.
Ketamine for PTSD: Emerging Evidence and Treatment Approaches
An evidence-based review of how ketamine therapy is being used to treat PTSD, including clinical trial data, proposed mechanisms, and how it compares to established treatments.
At-Home Ketamine: What Patients Should Know About Oral and Sublingual Options
A balanced look at oral and sublingual ketamine prescribed for at-home use — how it works, safety considerations, regulatory concerns, and how it compares to in-clinic treatment.
How to Choose a Ketamine Clinic: A Patient's Checklist
A practical checklist of what to look for — and what to ask — when evaluating ketamine clinics, including provider credentials, safety protocols, and red flags to avoid.